Protective effect of adenosine triphosphate against cisplatin-induced necrotic and degenerative oral mucositis in rats

Protective effect of adenosine triphosphate against cisplatin-induced necrotic and degenerative oral mucositis in rats

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Abstract Inflammation, oxidative damage, and adenosine triphosphate (ATP) depletion play a role in the pathogenesis of cisplatin (CIS)-induced here oral mucositis.Objective: The purpose of this research is to examine the impact of ATP against potential oral mucositis development in cisplatin-treated rats.Methodology All rats were randomly assigned to four groups, namely healthy control group (HG), ATP group (ATPG), Cisplatin group (CISG), and ATP + Cisplatin group (ATCS).

Firstly, ATP 4 mg/kg was administered via intraperitoneal injection (IP) to both ATPG and ATCS groups.The same volume of normal saline was injected into HG and CISG groups.After 1 h, cisplatin 5 mg/kg was administered via IP to CISG and ATCS groups.

The drugs were taken 1x1 for 7 d.Later, tongue tissues were collected from all groups.Biochemical, macroscopic, and histopathological examinations were performed on all tissues.

Results: ATP inhibited cisplatin-induced oxidative damage and pro-inflammatory cytokines levels in tongue tissue.In the CIS group, a significant number of distinct sulcus formations were found in the apex and corpus, as well as a few ulcer foci in the corpus, significant papilla loss, and bleeding.Meanwhile, in the ATP group, a similar appearance to healthy tissue was observed.

Histopathologically, it was determined that in cisplatin-aggravated tongue tissue damage, filiform papillae decreased when ATP was administered, and the arrangement and structures of the epithelium, blood capillaries, muscle groups, and adipose cell groups were normal.Conclusions: Oral veuve ambal rose mucositis caused by cisplatin is alleviated by ATP.These findings may be useful for developing new therapeutic approaches to prevent or treat mucositis, a side effect so severe that can lead to treatment discontinuation.